Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele.

doi:10.1176/jnp.15.3.354

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Article

Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele.

The Journal of neuropsychiatry and clinical neurosciences - 1 Jan 2003

Hirono Nobutsugu, Hashimoto Mamoru, Yasuda Minoru, Kazui Hirokazu, Mori Etsuro

Abstract excerpt

To investigate a possible effect of the apolipoprotein (APOE) epsilon4 allele on memory decline in Alzheimer's disease (AD), we examined 64 AD patients with the APOE epsilon3/3, epsilon3/4, or epsilon4/4 allele using the Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and its subtests at the initial examination and at the 1-year follow-up visit. One-year changes in the scores of the Word Recall...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Memory Disorders

Middle Aged

Neuropsychological Tests

Psychiatric Status Rating Scales

RNA, Messenger

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 12928512
DOI: 10.1176/jnp.15.3.354

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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