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Article

Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

15 Feb 1995

Abstract excerpt

BACKGROUND: Gene-modified tumor cell vaccines have shown efficacy in animal models of malignancy, including prostate cancer. Class I major histocompatibility complex (MHC) assembly and function in the cellular targets of such therapies is pivotal in determining the efficacy of specific cytokine-secreting tumor vaccines. PURPOSE: To help guide development of genetically engineered vaccine therapy for human...

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PMID: 7707419
DOI: 10.1093/jnci/87.4.280

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