Article
Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin.
Bone marrow transplantation - 1 May 2000
Delp K, Momburg F, Hilmes C, Huber C, Seliger B
Abstract excerpt
An association between oncogenic transformation and repression of different components of the MHC class I antigen processing machinery (APM) have been described in murine model systems. In order to discover whether a similar correlation exists, human tumor cell lines of distinct histology with altered ras protein were analyzed for the expression of APM components utilizing RT-PCR and Western blot analyses. A...
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