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Article

TAP expression provides a general method for improving the recognition of malignant cells in vivo.

Nature biotechnology - 1 May 2000

Alimonti J, Zhang Q J, Gabathuler R, Reid G, Chen S S, Jefferies W A

Abstract excerpt

A major class of tumors lack expression of the transporters associated with antigen processing (TAP). These proteins are essential for delivery of antigenic peptides into the lumen of the endoplasmic reticulum (ER) and subsequent assembly with nascent major histocompatibility complex (MHC) class I, which results in cell surface presentation of the trimeric complex to cytolytic T lymphocytes. Cytolytic T...

Read the complete abstract on PubMed

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Share to Antigen Presentation
Share to ATP Binding Cassette Transporter, Subfamily B, Member 2

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Share to Carcinoma, Small Cell

Share to CD4-Positive T-Lymphocytes

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Source

Identifiers

PMID: 10802618
DOI: 10.1038/75373

Genes

TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TAP expression provides a general method for improving the recognition of malignant cells in vivo.PMID 10802618Read ↗

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