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Article

Activation and involvement of Ral GTPases in colorectal cancer.

Cancer research - 1 Jan 2011

Martin Timothy D, Samuel Jonathan C, Routh Elizabeth D, Der Channing J, Yeh Jen Jen

Abstract excerpt

Current approaches to block KRAS oncogene function focus on inhibition of K-Ras downstream effector signaling. We evaluated the antitumor activity of selumetinib (AZD6244, ARRY-142886), a potent and selective MEK1/2 inhibitor, on a panel of colorectal carcinoma (CRC) cells and found no inhibition of KRAS mutant CRC cell anchorage-independent growth. Although AKT activity was elevated in KRAS mutant cells, and...

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Source

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Identifiers

PMID: 21199803
DOI: 10.1158/0008-5472.CAN-10-1517
PMCID: PMC3062918

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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