Epigenetic Inactivation of <i>SFRP</i> Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder Cancer

Abstract excerpt

In the United States each year, almost 13,000 deaths are attributable to bladder cancer, with the majority of these deaths related to higher stage, muscle-invasive solid tumors. Epigenetic silencing of the secreted frizzled receptor proteins (SFRP), antagonists of the WNT pathway, leads to constitutive WNT signaling, altering cell morphology and motility. Identifying alterations in this pathway in bladder cancer...

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