Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors.

The Journal of clinical investigation - 3 Aug 2026

Moreno-Vega Aura, Zambrano Macarena, Estrada-Virrueta Lilia, Meng Xiangyu, Puig Julia, Neyret-Kahn Helene, Shi Mingjun, Dufour Florent, Gilbert Guerric, Li Ke, Groeneveld Clarice, Fontugne Jacqueline, Pérez-Escavy Mercedes, Dhifli Wajdi, Hua Clément, Cabel Luc, Krucker Clémentine, Tanguy Laura, Lindskrog Sia Viborg, Beraud Claire, Langle Yanina V, Ye Tao, Tahi Fariza, Davidson Irwin, Paramio Jesus M, Dyrskjøt Lars, Allory Yves, Lluel Philippe, Eiján Ana Maria, Elati Mohamed, Radvanyi François, Lodillinsky Catalina, Bernard-Pierrot Isabelle

Abstract excerpt

Fibroblast growth factor receptor 3 (FGFR3) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly characterized. Here, we constructed an FGFR3-mutated GRN using a bottom-up bioinformatics approach, integrating transcriptomic data from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to Gene Regulatory Networks

Share to Neoplasm Proteins

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Tumor Suppressor Proteins

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42544574
DOI: 10.1172/JCI193280
PMCID: PMC13430010

Genes

FGFR3
GRN
TP63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors.PMID 42544574Read ↗

Role of FGFR3 in bladder cancer: Treatment landscape and future challenges.Semantic proximity Read ↗

FGFR3 alterations in bladder cancer: Sensitivity and resistance to targeted therapies.Semantic proximity Read ↗

Fibroblast growth factor receptor (FGFR) gene: pathogenesis and treatment implications in urothelial carcinoma of the bladder.Semantic proximity Read ↗

A place for precision medicine in bladder cancer: targeting the FGFRs.Semantic proximity Read ↗

Pan-cancer analysis and verification revealed the clinical significance of SLC9A3R1 in bladder cancer cohortSemantic proximity Read ↗

FGFR1/3 Signaling as an Achilles' Heel of Phenotypic Diversity in Urothelial Carcinoma.Semantic proximity Read ↗

FGFR3 – a Central Player in Bladder Cancer Pathogenesis?Semantic proximity Read ↗

Insights of fibroblast growth factor receptor 3 aberrations in pan-cancer and their roles in potential clinical treatment.Semantic proximity Read ↗

FGFR3 mutation characterization identifies prognostic and immune-related gene signatures in bladder cancer.Semantic proximity Read ↗

FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?†.Semantic proximity Read ↗

The Role of the Key Differentially Mutated Gene FGFR3 in the Immune Microenvironment of Bladder Cancer.Semantic proximity Read ↗

FGFR3 Mutations in Urothelial Carcinoma: A Single-Center Study Using Next-Generation SequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.