Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive integrative profiling of upper tract urothelial carcinomas.

Genome biology - 4 Jan 2021

Su Xiaoping, Lu Xiaofan, Bazai Sehrish Khan, Compérat Eva, Mouawad Roger, Yao Hui, Rouprêt Morgan, Spano Jean-Philippe, Khayat David, Davidson Irwin, Tannir Nizar N, Yan Fangrong, Malouf Gabriel G

Abstract excerpt

BACKGROUND: Crosstalk between genetic, epigenetic, and immune alterations in upper tract urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome are poorly understood. RESULTS: We perform an integrative genome- and methylome-wide profiling of diverse non-muscle-invasive and muscle-invasive upper tract urothelial carcinomas. In addition to mutations of FGFR3 and KDM6A, we identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Transitional Cell
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

Share to Histone Demethylases

Share to Immunity

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Transcriptome

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33397444
DOI: 10.1186/s13059-020-02230-w
PMCID: PMC7780630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive integrative profiling of upper tract urothelial carcinomas.PMID 33397444Read ↗

Integrated Genomic and Single-Cell Analysis Reveals Heterogeneity, Prognosis, and Treatment Vulnerability in Urothelial Carcinoma.Semantic proximity Read ↗

Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networksSemantic proximity Read ↗

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networksSemantic proximity Read ↗

Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signalingSemantic proximity Read ↗

Integrative analysis of the epigenetic basis of muscle-invasive urothelial carcinomaSemantic proximity Read ↗

Investigating cellular similarities and differences between upper tract urothelial carcinoma and bladder urothelial carcinoma using single-cell sequencingSemantic proximity Read ↗

Comprehensive genomic characterization of early-stage bladder cancer.Semantic proximity Read ↗

FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancerSemantic proximity Read ↗

The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder CancerSemantic proximity Read ↗

FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancerSemantic proximity Read ↗

Single-cell profiling reveals systemic immune reprogramming in muscle-invasive urothelial carcinomaSemantic proximity Read ↗

Integrative Analysis Reveals the Prognostic Effects of Epigenetic Regulators in Bladder CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.