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Article

Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events.

International journal of cancer - 1 Jul 2011

Serizawa Reza R, Ralfkiaer Ulrik, Steven Kenneth, Lam Gitte W, Schmiedel Sven, Schüz Joachim, Hansen Alastair B, Horn Thomas, Guldberg Per

Abstract excerpt

The bladder cancer genome harbors numerous oncogenic mutations and aberrantly methylated gene promoters. The aim of our study was to generate a profile of these alterations and investigate their use as biomarkers in urine sediments for noninvasive detection of bladder cancer. We systematically screened FGFR3, PIK3CA, TP53, HRAS, NRAS and KRAS for mutations and quantitatively assessed the methylation status of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Share to Receptor, Fibroblast Growth Factor, Type 3

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Source

Identifiers

PMID: 20824703
DOI: 10.1002/ijc.25651

Genes

FGFR3
APC
SFRP2
HRAS
KRAS
NRAS
RARB
SFRP1
SFRP4
SFRP5
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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