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Article

Promoter Hypermethylation in Tumour Suppressor Genes Shows Association with Stage, Grade and Invasiveness of Bladder Cancer

1 Jan 2008

Abstract excerpt

<i>Aims:</i> Superficial bladder cancer is a highly recurrent disease, with progression to muscle invasiveness occurring in 15–30% of cases. Promoter hypermethylation in a panel of tumour suppressor genes involved in cell cycle control, apoptosis and DNA repair was analyzed in superficial bladder tumours in order to evaluate the suitability of epigenetic biomarkers for an earlier prediction of the...

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Share to Bladder and Urothelial Cancer Treatments
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Share to Epigenetics and DNA Methylation

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PMID: 18824877
DOI: 10.1159/000158665

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