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Article

Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila.

Science (New York, N.Y.) - 12 Aug 2005

LaFever Leesa, Drummond-Barbosa Daniela

Abstract excerpt

Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can...

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Identifiers

PMID: 16099985
DOI: 10.1126/science.1111410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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