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Diet regulates membrane extension and survival of niche escort cells for germline homeostasis via insulin signaling

16 Mar 2018

Abstract excerpt

ABSTRACT Diet is an important regulator of stem cell homeostasis; however, the underlying mechanisms of this regulation are not fully known. Here, we report that insulin signaling mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein...

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PMID: 29549109
DOI: 10.1242/dev.159186

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