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Article

Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation.

The Journal of cell biology - 12 May 2014

Huang Jianhua, Kalderon Daniel

Abstract excerpt

It is essential to define the mechanisms by which external signals regulate adult stem cell numbers, stem cell maintenance, and stem cell proliferation to guide regenerative stem cell therapies and to understand better how cancers originate in stem cells. In this paper, we show that Hedgehog (Hh) signaling in Drosophila melanogaster ovarian follicle stem cells (FSCs) induces the activity of Yorkie (Yki), the...

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Identifiers

PMID: 24798736
DOI: 10.1083/jcb.201309141
PMCID: PMC4018789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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