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Article

Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2009

Alcantara Llaguno Sheila R, Chen Jian, Parada Luis F

Abstract excerpt

Malignant astrocytomas are infiltrative and aggressive brain tumors. Conventional forms of therapy have not been effective in controlling this incurable disease. Recent advances in understanding the molecular biology of these tumors have revealed potential mechanisms by which astrocytoma cells undergo tumor initiation, progression, and maintenance, as well as possible avenues for targeted therapeutics. Studies on...

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Identifiers

PMID: 19934302
DOI: 10.1158/1078-0432.CCR-09-0433
PMCID: PMC2787668

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