Article
Rapid and specific detection of clinically significant haemoglobinopathies using electrospray mass spectrometry-mass spectrometry.
British journal of haematology - 1 Aug 2005
Daniel Yvonne A, Turner Charles, Haynes Roberta M, Hunt Beverley J, Dalton R Neil
Abstract excerpt
Increasing demand for population screening for the haemoglobinopathies gives rise to a requirement for high throughput systems, which allow for cost effective, rapid, sensitive and specific screening of clinically significant haemoglobins. We have developed a practical and efficient approach using tryptic digestion and electrospray triple quadrupole mass spectrometry-mass spectrometry (MSMS) in multiple reaction...
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