Accurate mass measurement by electrospray ionization quadrupole mass spectrometry: detection of variants differing by <6 Da from normal in human hemoglobin heterozygotes.

doi:10.1021/ac026228h

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Article

Accurate mass measurement by electrospray ionization quadrupole mass spectrometry: detection of variants differing by <6 Da from normal in human hemoglobin heterozygotes.

Analytical chemistry - 1 May 2003

Rai Dilip K, Griffiths William J, Landin Britta, Wild Barbara J, Alvelius Gunvor, Green Brian N

Abstract excerpt

Mass spectrometry has a basic limitation when human hemoglobin variants are analyzed, because it cannot resolve two globin chains that differ in mass by <6 Da. Several common beta-chain variants differ by 1 Da from normal and, hence, when present in heterozygotes, are not resolved from the normal...

Topics

Calibration
Electrophoresis
Hemoglobins, Abnormal
Heterozygote
Humans
Mutation
Reproducibility of Results
Spectrometry, Mass, Electrospray Ionization

Source

Open in PubMed

Identifiers

PMID: 12720330
DOI: 10.1021/ac026228h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-12720330-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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