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Article

A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.

Molecular biology of the cell - 1 Oct 2005

Liu Zhengchang, Spírek Mário, Thornton Janet, Butow Ronald A

Abstract excerpt

Yeast cells respond to mitochondrial dysfunction by altering the expression of a subset of nuclear genes, a process known as retrograde signaling (RS). RS terminates with two transcription factors, Rtg1p and Rtg3p. One positive regulator, Rtg2p, and four negative regulators, Lst8p, Mks1p, and the redundant 14-3-3 proteins, Bmh1p and Bmh2p, control RS upstream of Rtg1/3p. Mks1p is negatively regulated by binding...

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PMID: 16093347
DOI: 10.1091/mbc.e05-06-0516
PMCID: PMC1237091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.PMID 16093347Read ↗

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Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways.Semantic proximity Read ↗

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GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeastSemantic proximity Read ↗

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