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Article

A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.

Molecular biology of the cell - 1 Oct 2005

Liu Zhengchang, Spírek Mário, Thornton Janet, Butow Ronald A

Abstract excerpt

Yeast cells respond to mitochondrial dysfunction by altering the expression of a subset of nuclear genes, a process known as retrograde signaling (RS). RS terminates with two transcription factors, Rtg1p and Rtg3p. One positive regulator, Rtg2p, and four negative regulators, Lst8p, Mks1p, and the...

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Identifiers

PMID: 16093347
DOI: 10.1091/mbc.e05-06-0516
PMCID: PMC1237091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16093347-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.PMID 16093347Read ↗

Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae.Semantic proximity Read ↗

Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p.Semantic proximity Read ↗

Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways.Semantic proximity Read ↗

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle.Semantic proximity Read ↗

Identification of She3 as an SCF(Grr1) substrate in budding yeast.Semantic proximity Read ↗

Genetic interaction between F-box motif encoding YDR131C and retrograde signaling-related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeastSemantic proximity Read ↗

Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae.Semantic proximity Read ↗

The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging.Semantic proximity Read ↗

The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.Semantic proximity Read ↗

MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5.Semantic proximity Read ↗

The kinase Isr1 negatively regulates hexosamine biosynthesis in <i>S. cerevisiae</i>Semantic proximity Read ↗

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