Article
Identification of She3 as an SCF(Grr1) substrate in budding yeast.
PloS one - 1 Jan 2012
Wang Ruiwen, Solomon Mark J
Abstract excerpt
The highly orchestrated progression of the cell cycle depends on the degradation of many regulatory proteins at different cell cycle stages. One of the key cell cycle ubiquitin ligases is the Skp1-cullin-F-box (SCF) complex. Acting in concert with the substrate-binding F-box protein Grr1, SCF(Grr1) promotes the degradation of cell cycle regulators as well as various metabolic enzymes. Using a yeast two-hybrid...
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