Article
Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.
BMC cancer - 9 Aug 2005
Allen-Brady Kristina, Camp Nicola J
Abstract excerpt
BACKGROUND: Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, MRE11A, XRCC4, NBS1 and RAD50. METHODS: The genes ATM, MRE11A, and XRCC4 were characterized...
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