Article

Modeling Cancer Genomic Data in Yeast Reveals Selection Against ATM Function During Tumorigenesis

2019-09-16

Abstract excerpt

The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor suppression. Components of the Mre11 complex are mutated in approximately five percent of human cancers. Inherited mutations of complex members cause severe chromosome i...

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Literature Corpus work: c127b31f-30bf-5676-bf41-b4e0f0f647dc
DOI: 10.1101/771253

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