Article
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
Nature genetics - 1 May 2009
Thomas Gilles, Jacobs Kevin B, Kraft Peter, Yeager Meredith, Wacholder Sholom, Cox David G, Hankinson Susan E, Hutchinson Amy, Wang Zhaoming, Yu Kai, Chatterjee Nilanjan, Garcia-Closas Montserrat, Gonzalez-Bosquet Jesus, Prokunina-Olsson Ludmila, Orr Nick, Willett Walter C, Colditz Graham A, Ziegler Regina G, Berg Christine D, Buys Saundra S, McCarty Catherine A, Feigelson Heather Spencer, Calle Eugenia E, Thun Michael J, Diver Ryan, Prentice Ross, Jackson Rebecca, Kooperberg Charles, Chlebowski Rowan, Lissowska Jolanta, Peplonska Beata, Brinton Louise A, Sigurdson Alice, Doody Michele, Bhatti Parveen, Alexander Bruce H, Buring Julie, Lee I-Min, Vatten Lars J, Hveem Kristian, Kumle Merethe, Hayes Richard B, Tucker Margaret, Gerhard Daniela S, Fraumeni Joseph F, Hoover Robert N, Chanock Stephen J, Hunter David J
Abstract excerpt
We conducted a three-stage genome-wide association study (GWAS) of breast cancer in 9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. In stage 1, we genotyped 528,173 SNPs in 1,145 cases of invasive breast cancer and 1,142 controls. In stage 2, we analyzed 24,909 top SNPs in 4,547 cases and 4,434 controls. In stage 3, we investigated 21 loci in 4,078 cases and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.