Article
Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.
PLoS genetics - 1 Mar 2020
Hohl Marcel, Mojumdar Aditya, Hailemariam Sarem, Kuryavyi Vitaly, Ghisays Fiorella, Sorenson Kyle, Chang Matthew, Taylor Barry S, Patel Dinshaw J, Burgers Peter M, Cobb Jennifer A, Petrini John H J
Abstract excerpt
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor suppression. Components of the Mre11 complex are mutated in approximately five percent of human cancers. Inherited mutations of complex members cause severe chromosome...
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