Genotoxicity of 3,6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo.

doi:10.1093/mutage/gep007

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Article

Genotoxicity of 3,6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo.

Mutagenesis - 1 May 2009

Kawanishi Masanobu, Watanabe Tetsushi, Hagio Soichiro, Ogo Sayaka, Shimohara Chiaki, Jouchi Rika, Takayama Saori, Hasei Tomohiro, Hirayama Teruhisa, Oda Yoshimitsu, Yagi Takashi

Abstract excerpt

3,6-Dinitrobenzo[e]pyrene (3,6-DNBeP), newly identified in airborne particles and surface soil, is a potent mutagen in Salmonella typhimurium. The present study investigated the genotoxic potency of 3,6-DNBeP in vitro and in vivo using mammalian cell strains (Chinese hamster CHL/IU and human HepG2) and ICR mice, respectively. In the hprt gene mutation assay using HepG2 cells, the spontaneous mutant frequency was...

Topics

Animals
Benzo(a)pyrene
Cell Line, Tumor
Comet Assay
Cricetinae
Cricetulus
DNA Primers
Environmental Pollutants
Histones
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred ICR

Micronucleus Tests

Molecular Structure

Mutation

Phosphorylation

Reverse Transcriptase Polymerase Chain Reaction

Sister Chromatid Exchange

Source

Open in PubMed

Identifiers

PMID: 19273466
DOI: 10.1093/mutage/gep007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19273466-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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