Article
Genotoxicity of 3,6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo.
Mutagenesis - 1 May 2009
Kawanishi Masanobu, Watanabe Tetsushi, Hagio Soichiro, Ogo Sayaka, Shimohara Chiaki, Jouchi Rika, Takayama Saori, Hasei Tomohiro, Hirayama Teruhisa, Oda Yoshimitsu, Yagi Takashi
Abstract excerpt
3,6-Dinitrobenzo[e]pyrene (3,6-DNBeP), newly identified in airborne particles and surface soil, is a potent mutagen in Salmonella typhimurium. The present study investigated the genotoxic potency of 3,6-DNBeP in vitro and in vivo using mammalian cell strains (Chinese hamster CHL/IU and human HepG2) and ICR mice, respectively. In the hprt gene mutation assay using HepG2 cells, the spontaneous mutant frequency was...
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