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Article

Gestational mutations and carcinogenesis.

Mathematical biosciences - 1 Oct 2005

Meza Rafael, Luebeck E Georg, Moolgavkar Suresh H

Abstract excerpt

We present a mathematical formulation to evaluate the effects of gestational mutations on cancer risk. The hazard or incidence function of cancer is expressed in terms of the Probability Generating Function (PGF) of the number of normal and mutated cells at birth. Using Filtered Poisson Process Theory, we obtain the PGF for several models for the accumulation of gestational mutations. In particular, we develop...

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PMID: 16087198
DOI: 10.1016/j.mbs.2005.06.003

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PGF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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