Article
Gestational age and gender-specific in utero V(D)J recombinase-mediated deletions.
Cancer research - 15 Apr 2001
Yoshioka M, O'Neill J P, Vacek P M, Finette B A
Abstract excerpt
Recent studies have brought to the forefront the importance of somatic mutations during human fetal development and malignant transformation in children, specifically leukemia. Therefore, a better understanding of the frequency and mutational spectrum of spontaneous in utero mutations is essential for understanding the genetic mechanisms associated with pediatric malignancies. Previously we reported that the...
Topics
- Base Sequence
- Chromosome Breakage
- DNA Mutational Analysis
- DNA Nucleotidyltransferases
- Female
- Fetal Blood
- Gene Deletion
- Gestational Age
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Infant, Newborn
- Infant, Premature
- Logistic Models
- Male
- Molecular Sequence Data
- Mutation
- Sex Factors
- T-Lymphocytes