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Article

Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F₂ male offspring via the F₁ male offspring.

Journal of applied toxicology : JAT - 1 Jan 2016

Nohara Keiko, Okamura Kazuyuki, Suzuki Takehiro, Murai Hikari, Ito Takaaki, Shinjo Keiko, Takumi Shota, Michikawa Takehiro, Kondo Yutaka, Hata Kenichiro

Abstract excerpt

Gestational exposure can affect the F2 generation through exposure of F1 germline cells. Previous studies reported that arsenite exposure of only F0 females during their pregnancy increases hepatic tumors in the F1 males in C3H mice, whose males are predisposed spontaneously to develop hepatic tumors later in life. The present study addressed the effects of gestational arsenite exposure on tumorigenesis of the F2...

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Source

Identifiers

PMID: 25825268
DOI: 10.1002/jat.3149

Genes

CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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