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Article

Prolonged unbalanced growth induces cellular senescence markers linked with mechano transduction in normal and tumor cells.

Biochemical and biophysical research communications - 23 Sept 2005

Sumikawa Emi, Matsumoto Yuko, Sakemura Risa, Fujii Michihiko, Ayusawa Dai

Abstract excerpt

Cellular senescence is induced by diverse means and hence thought to be mediated by multiple pathways. We show that prolonged unbalanced growth due to retardation of DNA replication elicits a senescence-like phenomenon irrespective of the cell type. In fact, modest inhibition of DNA replication by various means led to cell swelling, cytoskeletal alterations, and irregularly enlarged, flat cell shape. Such cells...

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Identifiers

PMID: 16083852
DOI: 10.1016/j.bbrc.2005.07.106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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