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Article

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002

Chang Bey-Dih, Swift Mari E, Shen Mei, Fang Jing, Broude Eugenia V, Roninson Igor B

Abstract excerpt

Treatment with chemotherapy or radiation is not invariably cytotoxic to all tumor cells. Some of the cells that survive treatment recover and resume proliferation, whereas others undergo permanent growth arrest. To understand the nature of treatment-induced terminal growth arrest, colon carcinoma cells were exposed to doxorubicin, and surviving cells were separated into proliferating and growth-arrested...

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Identifiers

PMID: 11752408
DOI: 10.1073/pnas.012602599
PMCID: PMC117570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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