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Radiation-induced cellular senescence results from a slippage of long-term G<sub>2</sub>arrested cells into G<sub>1</sub>phase

1 May 2013

Abstract excerpt

Diploid cells undergoing senescence and mitotic slippage have been reported in the literature. However, the mechanisms triggering senescence in long-term G2-arrested cells are currently unclear. Previously, we reported that the cell cycle of the human uveal melanoma cell line, 92-1, is suspended for up to 6 d upon exposure to 10 Gy ionizing radiation (IR), followed by senescence. In the current study, we...

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PMID: 23574719
DOI: 10.4161/cc.24528

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