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Article

The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence.

Cell cycle (Georgetown, Tex.) - 1 Mar 2005

Klein Laura E, Freeze B Scott, Smith Amos B, Horwitz Susan Band

Abstract excerpt

Discodermolide is a microtubule stabilizing agent that suppresses dynamic instability and blocks cells in mitosis. Selection of A549 nonsmall cell lung carcinoma cells with increasing concentrations of discodermolide yielded a clone that proliferated in 8 nM. When these cells were exposed to any concentration greater than 8 nM, replication ceased and the cells developed a flattened, enlarged, granular morphology....

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Identifiers

PMID: 15711127
DOI: 10.4161/cc.4.3.1550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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