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CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence

1 Nov 2023

Abstract excerpt

Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER2- breast cancer. We demonstrate that CDK4/6-inhibited cells overgrow during G0/G1, causing p38/p53/p21-dependent...

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PMID: 37977118
DOI: 10.1016/j.molcel.2023.10.016

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