Article
A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.
Cell cycle (Georgetown, Tex.) - 1 Aug 2005
Grishina Irina, Lattes Bradford
Abstract excerpt
Initiation of DNA replication in eukaryotic cells depends on the assembly of the prereplication complexes containing two hexamers, the Origin Recognition Complex (ORC) and the Minichromosome maintenance/DNA Replication Licensing complex (MCM); and on the subsequent conformational changes in the MCM complex leading to the formation of a competent DNA replication complex, firing of the DNA polymerase and...
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