Article
Management of gene promoter mutations in molecular diagnostics.
Clinical chemistry - 1 Apr 2009
de Vooght Karen M K, van Wijk Richard, van Solinge Wouter W
Abstract excerpt
BACKGROUND: Although promoter mutations are known to cause functionally important consequences for gene expression, promoter analysis is not a regular part of DNA diagnostics. CONTENT: This review covers different important aspects of promoter mutation analysis and includes a proposed model procedure for studying promoter mutations. Characterization of a promoter sequence variation includes a comprehensive study...
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