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Assessment of tumor suppressor promoter methylation in healthy individuals

28 Aug 2020

Abstract excerpt

BACKGROUND: The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methylation of BRCA1 and MLH1 to ovarian and colon cancer risk, the role of epigenetic alterations as cancer risk factors remains largely unknown, presenting an important area for future research....

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PMID: 32859265
DOI: 10.1186/s13148-020-00920-7

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