A Common Haplotype on<i>Methylenetetrahydrofolate Reductase</i>Gene Modifies the Effect of Angiotensin-Converting Enzyme Inhibitor on Blood Pressure in Essential Hypertension Patients—A Family-Based Association Study

Abstract excerpt

Our recent study indicated that MTHFR C677T polymorphism may involve in genetic control of blood pressure response to treatment by benazepril, an ACE inhibitor. Currently, we proposed to further investigate whether short-term blood pressure response to benazepril, was modulated by haplotypes re-constructed from both C677T and A1298C polymorphisms in MTHFR gene. A total of 410 hypertensive patients recruited from...

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