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Article

Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: a systematic review and meta-analysis.

Metabolism: clinical and experimental - 1 Dec 2014

Wu Yi-Le, Hu Cai-Yun, Lu Shan-Shan, Gong Feng-Feng, Feng Fang, Qian Zhen-Zhong, Ding Xiu-Xiu, Yang Hui-Yun, Sun Ye-Huan

Abstract excerpt

OBJECTIVE: Many studies have investigated the role of 5,10-methylenetetrahydrofolate reductase gene (MTHFR) C677T/A1298C polymorphisms in essential hypertension (EH), but results are inconclusive. The purpose of this meta-analysis was to clarify the effects of MTHFR C677T/A1298C polymorphisms on the risk of EH. METHODS: Electronic databases were searched to identify relevant studies published until January 2014....

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Source

Identifiers

PMID: 25458833
DOI: 10.1016/j.metabol.2014.10.001

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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