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Article

Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility.

International journal of environmental research and public health - 17 Jun 2016

Fan Shujun, Yang Boyi, Zhi Xueyuan, Wang Yanxun, Wei Jian, Zheng Quanmei, Sun Guifan

Abstract excerpt

Hypertension is considered to be the result of genes, environment, and their interactions. Among them age, sex, tobacco use, alcohol consumption, and being overweight/obesity are well documented environmental determinants, and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is nominated as a potential genetic candidate. However, the synergistic effect of the MTHFR C677T polymorphism with these...

Topics

Alcohol Drinking
Alleles
Asian People
China
Female
Genetic Predisposition to Disease
Genotype
Humans
Hypertension
Male
Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Overweight

Polymorphism, Genetic

Risk Factors

Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 27322299
DOI: 10.3390/ijerph13060601
PMCID: PMC4924058

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27322299-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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