Article
The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor.
Thrombosis research - 1 Jan 2004
Jiang Shanqun, Hsu Yi-Hsiang, Xu Xin, Xing Houxun, Chen Changzhong, Niu Tianhua, Zhang Yan, Peng Shaojie, Xu Xiping
Abstract excerpt
OBJECTIVES: Elevated plasma homocysteine has been implicated as a risk factor for hypertension. C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction. Angiotensin-converting enzyme (ACE) inhibitors appear to remedy the endothelial dysfunction and restore endothelium-dependent vasodilatation. The co-existence...
Topics
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Benzazepines
- Blood Pressure
- China
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genetic Variation
- Humans