Article
Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium.
Cancer research - 15 Dec 2011
Shete Sanjay, Lau Ching C, Houlston Richard S, Claus Elizabeth B, Barnholtz-Sloan Jill, Lai Rose, Il'yasova Dora, Schildkraut Joellen, Sadetzki Siegal, Johansen Christoffer, Bernstein Jonine L, Olson Sara H, Jenkins Robert B, Yang Ping, Vick Nicholas A, Wrensch Margaret, Davis Faith G, McCarthy Bridget J, Leung Eastwood Hon-chiu, Davis Caleb, Cheng Rita, Hosking Fay J, Armstrong Georgina N, Liu Yanhong, Yu Robert K, Henriksson Roger, Melin Beatrice S, Bondy Melissa L
Abstract excerpt
Gliomas, which generally have a poor prognosis, are the most common primary malignant brain tumors in adults. Recent genome-wide association studies have shown that inherited susceptibility plays a role in the development of glioma. Although first-degree relatives of patients exhibit a two-fold increased risk of glioma, the search for susceptibility loci in familial forms of the disease has been challenging...
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