Article
Maternal lineages and Alzheimer disease risk in the Old Order Amish.
Human genetics - 1 Oct 2005
van der Walt Joelle M, Scott William K, Slifer Susan, Gaskell P C, Martin Eden R, Welsh-Bohmer Kathleen, Creason Marilyn, Crunk Amy, Fuzzell Denise, McFarland Lynne, Kroner Charles C, Jackson C E, Haines Jonathan L, Pericak-Vance Margaret A
Abstract excerpt
Old Order Amish, founded by a small number of Swiss immigrants, exist in culturally isolated communities across rural North America. The consequences of genetic isolation and inbreeding within this group are evident by increased frequencies of many monogenic diseases and several complex disorders. Conversely, the prevalence of Alzheimer disease (AD), the most common form of dementia, is lower in the Amish than in...
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