Article
Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies.
Nucleic acids research - 2 Aug 2005
Zhong Xiao-bo, Leng Lin, Beitin Anna, Chen Rui, McDonald Courtney, Hsiao Betty, Jenison Robert D, Kang Insoo, Park Sung-Hwan, Lee Annette, Gregersen Peter, Thuma Philip, Bray-Ward Patricia, Ward David C, Bucala Richard
Abstract excerpt
Microsatellite repeat and single nucleotide polymorphisms (SNPs) are abundant sources of genetic variation, but existing methodologies cannot simultaneously detect these variants in a facile or inexpensive way. We describe herein a thin-film biosensor chip based on an allele-discriminating oligonucleotide array that enables genotyping for both microsatellite repeats and SNPs in a single analysis. We validated...
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