Article
Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity.
The Journal of biological chemistry - 23 Sept 2005
Medunjanin Senad, Hermani Alexander, De Servi Barbara, Grisouard Jean, Rincke Gabriele, Mayer Doris
Abstract excerpt
Like other steroid hormone receptors, estrogen receptor-alpha (ERalpha) is a substrate for protein kinases, and phosphorylation has profound effects on the function and activity of this receptor. A number of different kinases have been implicated in ERalpha regulation. In this report we show by mutational analysis and in vitro kinase assays that ERalpha is a substrate for glycogen synthase kinase-3 (GSK-3) in...
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