Article
Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2008
Picard Nathalie, Charbonneau Catherine, Sanchez Mélanie, Licznar Anne, Busson Muriel, Lazennec Gwendal, Tremblay André
Abstract excerpt
The ubiquitin-proteasome pathway has been recognized as an important regulator in the hormonal response by estrogen receptor (ER) alpha, but its impact on ERbeta function is poorly characterized. In the current study, we investigated the role of the ubiquitin-proteasome pathway in regulating ERbeta activity and identified regulatory sites within the activation function (AF)-1 domain that modulate ERbeta...
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