Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice.

doi:10.1111/j.1365-2249.1992.tb06473.x

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Article

Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice.

Clinical and experimental immunology - 1 Jun 1992

Holmdahl R, Jansson L, Andersson M, Jonsson R

Abstract excerpt

DBA/1 male mice develop arthritis spontaneously at the age of 4 months. The affected joints show cell-rich pannus formation without T cell infiltration and only limited MHC class II expression. Specific pathogen-free DBA/1 mice from different sources developed the same disease. Analyses of inbred mouse strains with various genetic backgrounds and F1 hybrids revealed that the disease is genetically dependent of...

Topics

Animals
Antigens
Arthritis
Behavior, Animal
Castration
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease
Germ-Free Life
Hybridization, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Male

Mice

Mice, Inbred Strains

Testosterone

Time Factors

Source

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Identifiers

PMID: 1606732
DOI: 10.1111/j.1365-2249.1992.tb06473.x
PMCID: PMC1554520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1606732-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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