Article
Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice.
Clinical and experimental immunology - 1 Jun 1992
Holmdahl R, Jansson L, Andersson M, Jonsson R
Abstract excerpt
DBA/1 male mice develop arthritis spontaneously at the age of 4 months. The affected joints show cell-rich pannus formation without T cell infiltration and only limited MHC class II expression. Specific pathogen-free DBA/1 mice from different sources developed the same disease. Analyses of inbred mouse strains with various genetic backgrounds and F1 hybrids revealed that the disease is genetically dependent of...
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