Article
Male New Zealand Black/KN mice: a novel model for autoimmune-induced permanent alopecia?
The British journal of dermatology - 1 Aug 2006
Hiroi A, Ito T, Seo N, Uede K, Yoshimasu T, Ito M, Nakamura K, Ito N, Paus R, Furukawa F
Abstract excerpt
BACKGROUND: Irreversible, permanent and scarring alopecia is associated with several autoimmune diseases, including all autoimmune connective tissue disorders. The pathogenesis of autoimmune-induced permanent alopecia (APA) is still poorly understood, and instructive, simple mouse models for the study of APA are needed urgently. During the course of our studies in a well-established mouse model for chronic...
Topics
- Aging
- Alopecia
- Animals
- Autoimmune Diseases
- Basement Membrane
- Disease Models, Animal
- Female
- Fluorescent Antibody Technique, Direct
- Fluorescent Antibody Technique, Indirect
- Genes, MHC Class I
- Genetic Predisposition to Disease
- Hair
- Hair Follicle