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Article

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

1 Aug 2005

Abstract excerpt

Damage recognition by repair/checkpoint factors is the critical first step of the DNA damage response. DNA double strand breaks (DSBs) activate checkpoint signaling and are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR) pathways. However, in vivo kinetics of the individual factor responses and the mechanism of pathway choice are not well understood. We report cell cycle and time...

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PMID: 16061690
DOI: 10.1083/jcb.200411083

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