Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

Abstract excerpt

The integrity of genome is a prerequisite for healthy life. Indeed, defects in DNA repair have been associated with several human diseases, including tissue-fibrosis, neurodegeneration and cancer. Despite decades of extensive research, the spatio-mechanical processes of double-strand break (DSB)-repair, especially the auxiliary factor(s) that can stimulate accurate and timely repair, have remained elusive. Here,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Glycation End Products research
• Share to DNA Repair Mechanisms
• Share to Telomeres, Telomerase, and Senescence