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Article

Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence.

Molecular and cellular biology - 1 Aug 2005

Sarkar Devanand, Park Eun Sook, Emdad Luni, Randolph Aaron, Valerie Kristoffer, Fisher Paul B

Abstract excerpt

To fully comprehend cellular senescence, identification of relevant genes involved in this process is mandatory. Human polynucleotide phosphorylase (hPNPase(OLD-35)), an evolutionarily conserved 3', 5' exoribonuclease mediating mRNA degradation, was first identified as a predominantly mitochondrial protein overexpressed during terminal differentiation and senescence. Overexpression of hPNPase(OLD-35) in human...

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Identifiers

PMID: 16055741
DOI: 10.1128/MCB.25.16.7333-7343.2005
PMCID: PMC1190265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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