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Article

PNPase knockout results in mtDNA loss and an altered metabolic gene expression program.

PloS one - 1 Jan 2018

Shimada Eriko, Ahsan Fasih M, Nili Mahta, Huang Dian, Atamdede Sean, TeSlaa Tara, Case Dana, Yu Xiang, Gregory Brian D, Perrin Benjamin J, Koehler Carla M, Teitell Michael A

Abstract excerpt

Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders. To reveal role(s) for PNPase in mitochondria, we established PNPase knockout (PKO) systems by first shifting culture conditions to enable cell growth with defective respiration. Interestingly, PKO established in mouse embryonic fibroblasts (MEFs) resulted in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30024931
DOI: 10.1371/journal.pone.0200925
PMCID: PMC6053217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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