Identification and cloning of human polynucleotide phosphorylase, <i>hPNPase</i> ^{<i>old-35</i>} , in the context of terminal differentiation and cellular senescence

Abstract excerpt

Terminal differentiation and cellular senescence display common properties including irreversible growth arrest. To define the molecular and ultimately the biochemical basis of the complex physiological changes associated with terminal differentiation and senescence, an overlapping-pathway screen was used to identify genes displaying coordinated expression as a consequence of both processes. This approach...

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